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Diabetes, hypertension, and cardiovascular disease all raise the risk of hospitalization and mortality in individuals infected with coronavirus disease 2019 (COVID-19). Higher levels of flogosis mediators such as TNF, C-reactive protein (CRP), IL-1, IL-6, leptin, and resistin, as well as increased levels of TNF, C-reactive protein (CRP), IL-1, IL-6, leptin, and resistin, define diabetes. The goal of this study is to evaluate the levels of D-dimer, total serum bilirubin (TSB), glutamic-oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and CRP in diabetic patients with COVID-19 infection to COVID-19 patients without diabetes. Blood samples were collected from individuals with diabetes who had COVID-19 and non-diabetic COVID patients as control. Moreover, D-dimer and CRP were evaluated by using Min Vidus and Latx, respectively, whereas AccEnT 200 system was used to measure the serum level of TSB, GPT, and GOT in the hematology lab. Also demonstrated that the average serum concentration of D-dimer, GOT and CRP was high in diabetic COVID-19-infected patients (980.66 ng/mL, 67.71 U/L, and 27.06 mg/L, respectively) compared with non-diabetic COVID-19-infected patients (791.17 ng/mL, 54.023 U/L and 20.11 mg/L, respectively) (p < 0.05), while the situation was inverse for the average concentration of TSB and GTP when their average concentrations were low in diabetic COVID-19-infected patients (12.89 Mmol/L and 59.79 U/L, respectively) (p > 0.05). Moreover, the cut-off values for serum D-dimer, TSB, GPT, GOT, and CRP of COVID-19-infected diabetic patients were ≥ 6500 ng/mL, ≥ 350 Mmol/L, ≥ 133 U/L mg/L, ≥ 150 U/L, and ≥ 15.22 mg/L, respectively, represented a perfect test for predicting COVID-19-infected diabetic patients with 100% sensitivity and specificity. In conclusion, serum D-dimer, TSB, GPT, GOT and CRP increased in diabetic COVID-19-infected patients compared to non-diabetic COVID-19 patients and the D-dimer concentration also increases. TSB and CRP were more pronounced among diabetic patients with corona, while liver enzyme concentrations were decreased.
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Background: The societal challenges presented by fear related to the coronavirus disease (COVID-19) pandemic may present unique challenges for an individual's mental health. However, the moderating role of compassion in the relationship between fear of COVID-19 and mental health has not been well-studied. The present study aimed to explore the association between fear of COVID-19 and mental health, as well as test the buffering role of compassion in this relationship. Methods: The participants in this study were 325 Iranian undergraduate students (228 females), aged 18-25 years, who completed questionnaires posted on social networks via a web-based platform. Results: The results showed that fear of COVID-19 was positively related with physical symptoms, social function, depressive symptoms, and anxiety symptoms. The results also showed that compassion was negatively associated with physical symptoms, social function, depressive symptoms, and anxiety symptoms. The interaction-moderation analysis revealed that compassion moderated the relationship between fear of COVID-19 and subscale of mental health. Conclusion: Results highlight the important role of compassion in diminishing the effect of fear of COVID-19 on the mental health (physical symptoms, social function, depressive symptoms, and anxiety symptoms) of undergraduate students.
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The rapid spread of the SARS-Cov-2 virus, the increase in the number of patients with severe COVID-19, and the high mortality rate created the basis for the production of safe and effective vaccines. Studies have confirmed the increased risk of severe Covid-19 disease and mortality in cancer patients. It is logical that cancer patients should be the first to receive the primary vaccination and the booster vaccine for Covid-19. Since studies related to cancer patients and the effectiveness of existing Covid-19 vaccines have not been widely conducted, there are significant uncertainties about the effectiveness of the vaccine and the level of humoral and cellular immune responses in these patients. As a result, the possible risks and side effects of existing vaccines are not clear for patients with different cancers who are undergoing special treatments. In this study, we will discuss the effectiveness and safety of existing vaccines on cancer patients. In addition, we highlight factors that could affect the effectiveness of vaccines in these patients and finally discuss opportunities and challenges related to vaccination in cancer patients.
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Background The societal challenges presented by fear related to the coronavirus disease (COVID-19) pandemic may present unique challenges for an individual's mental health. However, the moderating role of compassion in the relationship between fear of COVID-19 and mental health has not been well-studied. The present study aimed to explore the association between fear of COVID-19 and mental health, as well as test the buffering role of compassion in this relationship. Methods The participants in this study were 325 Iranian undergraduate students (228 females), aged 18–25 years, who completed questionnaires posted on social networks via a web-based platform. Results The results showed that fear of COVID-19 was positively related with physical symptoms, social function, depressive symptoms, and anxiety symptoms. The results also showed that compassion was negatively associated with physical symptoms, social function, depressive symptoms, and anxiety symptoms. The interaction-moderation analysis revealed that compassion moderated the relationship between fear of COVID-19 and subscale of mental health. Conclusion Results highlight the important role of compassion in diminishing the effect of fear of COVID-19 on the mental health (physical symptoms, social function, depressive symptoms, and anxiety symptoms) of undergraduate students.
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Introduction: SARS-CoV-2 causes severe acute respiratory syndrome prompting worldwide demand for new antiviral treatments and supportive care for organ failure caused by this life-threatening virus. This study aimed to help develop a new Traditional Persian Medicine (TPM) -based drug and assess its efficacy and safety in COVID-19 patients with major symptoms. Methods: In February 2022, a randomized clinical trial was conducted among 160 patients with a confirmed diagnosis of COVID-19 admitted to Emam Reza (AJA) Hospital in Tehran, Iran. During their hospitalization, the intervention group received a treatment protocol approved by Iran's Ministry of Health and Medical Education (MOHME), consisting of an Iranian regimen, Ficus carica; Vitis vinifera, Safflower, Cicer arietinum, Descurainiasophia seeds, Ziziphus jujuba, chicken soup, barley soup, rose water, saffron, and cinnamon spices. All patients were compared in terms of demographics, clinical, and laboratory variables. Results: One hundred and sixty COVID-19 patients were divided into two groups: intervention and control. In baseline characteristics, there was no significant difference between the intervention and control groups (p>0.05). Using SPSS software version 22, statistical analysis revealed a significant difference in four symptoms: myalgia, weakness, headache, and cough (p<0.05). During the 5-day treatment period, the control group had significantly lower C-reactive protein (p<0.05). Conclusion: While more research with a larger sample size is needed, the proposed combination appears to be effective in the treatment of symptoms as well as inflammatory biomarkers such as C-reactive protein in COVID-19 patients.Iranian registry of clinical trials (IRCT) IRCT20220227054140N1.
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In response to the COVID-19 pandemic, single-use disposable masks saw a dramatic rise in production. Facial masks that are not properly disposed of will expose the environment to a form of non-biodegradable plastic waste that will take hundreds of years to degrade. Therefore, recycling such waste in an eco-friendly manner is imperative. Fibered or shredded waste masks can be used to make green concrete that is an environmentally friendly solution to dispose the facial masks. This study prepared six classes of concrete samples, three of which contained fibers from masks and three of which contained shredded masks at the ages of seven days and 28 days. The results show that in the seven-day and 28-day samples, mask fiber added to the mixes resulted in increased compressive strength. For seven-day and 28-day samples, the compressive strength increased by 7.2% and 10%, respectively. Despite that, the results of the shredded mask addition to concrete indicate that the increase in shredded mask volume has a minor impact on the compressive strength of the seven-day samples. An increase in shredded mask from 0.75 to 1% increased 28-day compressive strength by 14%. However, the compressive strength of the mask fiber decreased by 8 after 1% volume. According to a thermal analysis of 28-day concrete samples, as the fiber percentage increases, the mass loss percentage increases. The mass loss rate for samples containing fibers is higher than that for samples containing shredded mask pieces. In general, based on the results mentioned above, the use of fiber in concrete in its fiber state enhances its strength properties. As a result, using shredded mask pieces in concrete leads to better curing due to the reduction of residual capillary pore water loss in construction materials.
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The field of immunometabolism investigates and describes the effects of metabolic rewiring in immune cells throughout activation and the fates of these cells. Recently, it has been appreciated that immunometabolism plays an essential role in the progression of viral infections, cancer, and autoimmune diseases. Regarding COVID-19, the aberrant immune response underlying the progression of diseases establishes two major respiratory pathologies, including acute respiratory distress syndrome (ARDS) or pneumonia-induced acute lung injury (ALI). Both innate and adaptive immunity (T cell-based) were impaired in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Current findings have deciphered that macrophages (innate immune cells) are involved in the inflammatory response seen in COVID-19. It has been demonstrated that immune system cells can change metabolic reprogramming in some conditions, including autoimmune diseases, cancer, and infectious disease, including COVID-19. The growing findings on metabolic reprogramming in COVID-19 allow an exploration of metabolites with immunomodulatory properties as future therapies to combat this hyperinflammatory response. The elucidation of the exact role and mechanism underlying this metabolic reprograming in immune cells could help apply more precise approaches to initial diagnosis, prognosis, and in-hospital therapy. This report discusses the latest findings from COVID-19 on host metabolic reprogramming and immunometabolic responses.